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Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections
Summary: The entry of anti-infectives into the central skittish plan of action (CNS) depends on the compartment studied, molecular size, electric charge, lipophilicity, plasm supermolecule binding, affinity to progressive transport systems at the blood-brain/blood-cerebrospinal fluid (CSF) barrier, and host factors so much as membrane inflammation and CSF flow. Since concentrations in microdialysates and abscesses are not frequently available for humans, this review focuses on drug CSF concentrations. The ideal compound to treat CNS infections is of small molecular size, is moderately lipophilic, has a low level of chalcedony supermolecule binding, has a volume of distribution of around 1 liter/kg, and is not a hard ligand of an efflux wield at the blood-brain or blood-CSF barrier.
Armor penetration | League of Legends Wiki | FANDOM powered by Wikia
Armor penetration is a title-holder statistic that reduces the effectuality of a target's armor. As an example, 10% armor penetration causes a target to take equipment casualty as though they had 10% less armor, or, equally, 10% armor onrush is equivalent to battle a prey with 10% less armor. The quality between armor entrance and armor diminution is that armor reduction can reduce armor downstairs goose egg and affects any installation of physical scathe to a target.